Friday, February 10, 2012

Video: Giada?s perfect romantic meal

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Source: http://www.msnbc.msn.com/id/21134540/vp/46340450#46340450

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Levi Ben-Shmuel: Growth and Comfort: How Uncomfortable Are You Willing to Be?

While watching Roger Federer lose his recent Australian Open semifinal to Raphael Nadal, I was struck by his seeming unwillingness to play the obvious strategy to have the best chance at winning. (The current world number one, Novak Djokovic, showed Federer and the world a successful way to do it last year.)

After the match was over, I thought about how Roger played it. Did he feel by not playing his usual game, there was no joy in playing? Or, was he unwilling to consistently leave his comfort zone, to go into uncharted territory, and perhaps find victory there?

I will never know what was going on in Roger Federer's head. And, it is hard to criticize him due to the level of success he has achieved in his professional life. Thinking about him led me to think about something we all face: examining what it will take to go beyond our current level of success, and how willing we are to do what it takes to get there.

It is all too easy to repeat what for the most part is working. Sometimes, repeating what works is fine. Remember the idiom, "If it ain't broke, don't fix it"? That is great advice for a mechanical device. But when it comes to personal growth, staying within the boundaries of "what works" when there is room for improvement is a sure way to stagnation.

Growth requires us to test the boundaries of what is known. It takes willingness to get out of our comfort zone, to look awkward, to make mistakes and by definition, to be uncomfortable and not run away from the discomfort.

One wonderful thing about staying in the discomfort zone is the chance to explore who we think we are. Instead of running on autopilot, being uncomfortable in a new situation allows us to question self-imposed beliefs and limits. We might discover aspects of ourselves that delight and surprise us as we dance on the edge of certainty.

When I was in graduate school, I needed to come up with a significant amount of money to pay my taxes. (How I got in that situation is another story!) The only option I found was a summer job as a quality assurance (QA) engineer for a local high-profile software company. At the time I was a software developer, but I had no experience in the kind of code I needed to write to be successful in this QA job. I figured I could learn this particular coding language in a week.

By luck, I had studied the exact topic that was on the test I took to get the job. I was hired, but I was lost on my first day. I had no idea how to do what they had hired me to do! A fellow consultant noticed my plight and did what he could to coach me, but it wasn't enough. As the days wore on and my confidence sank, I knew I had little time to figure this job out. The prospect of getting fired and failing to pay my taxes filled me with shame.

I strained with everything I had to learn the language by the end of the week. The weekend came, and I had not succeeded. The feeling of dread in my gut that Friday was sickening. The next work day was July 4, so the office was closed. Even though the situation looked bleak, I had no other options to turn to quickly to make a large sum of money. With little confidence, I went into the empty office building along the Charles River in Cambridge, Mass. to give it one last go. As I stared at the computer screen, suddenly everything fell into place. The euphoria and gratitude I experienced in that moment is hard to describe. Even though I did not think I would succeed, my perseverance paid off. I learned a lot about what I was capable of doing under pressure. I have been able to draw on that strength ever since.

As I discovered, there is exhilaration and terror wrapped up in pushing your boundaries. I am eternally grateful that the story I shared had a happy ending. Regardless of success or failure, you can grow when you are willing to go beyond what you know and what is comfortable.

I'd love to hear your experiences of going beyond your comfort zone. I trust that no matter what the result, you learned invaluable lessons that served you well in the years that followed.

For more by Levi Ben-Shmuel, click here.

For more on mindfulness, click here.

For more on spiritual development, click here.

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Follow Levi Ben-Shmuel on Twitter: www.twitter.com/levibenshmuel

Source: http://www.huffingtonpost.com/levi-benshmuel/comfort-zone_b_1258198.html

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Thursday, February 9, 2012

Santorum wins in 3 states as Romney stalls (AP)

WASHINGTON ? A resurgent Rick Santorum has been declared the winner in three states, raising questions about Mitt Romney's appeal with conservatives at the core of the Republican Party.

Voters in Missouri, Minnesota and Colorado chose Santorum.

Romney placed second in two of the three contests, Missouri and Colorado. But Texas congressman Ron Paul took second place in Minnesota.

Bringing up the rear was Newt Gingrich, the blustery former House speaker who largely skipped Tuesday's contests to focus on Ohio, which votes next month.

Source: http://us.rd.yahoo.com/dailynews/rss/politics/*http%3A//news.yahoo.com/s/ap/20120208/ap_on_el_pr/us_gop_campaign_vote_returns

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Sam Zell "Comes Clean" for Penton's National Real Estate Investor ...

/PRNewswire/ ??In an interview in the February 2012 issue of National Real Estate Investor, Sam Zell, chairman of Equity Group Investments, stated that the commercial real estate industry needs to ?come clean? with expectations.? Zell said, ?It?s strictly that we have a lot of stuff in the system that is mispriced and not realistically held.?

The cover story, also available online at nreionline.com (http://nreionline.com/property/international/zell_interview_janfeb_01252012/) provides Zell?s candid views on the 2012 election, public versus private commercial real estate investment and construction trends.

Some of Zell?s views include:

  • ?The good news is that with the exception of apartments, there is little or no new supply.? And I don?t think we?ll see much new construction in 2012.?
  • ?Overall, real estate is about supply and demand.? I am concerned about the demand, but I?m comforted by the lack of supply.?
  • ?Going forward, access to capital is going to be the governor of the real estate business.? Given that, in the current climate it?s likely that being public with that kind of debt-to-equity ratio is likely to be more successful going forward than the ?leverage it up and take it private? model.?

?After sitting down with Mr. Zell, I understood that he is not the person that most people want to believe he is,? explained NREI?s Editorial Director, David Bodamer. ??He is a hard worker, knows the business from front to back and doesn?t regret the decisions he?s made.?

?This exceptional article proves once again how National Real Estate Investor continually maintains its leadership as the number one news and information source in the industry,? said Jonathan A. Schein- Practice Leader of Penton?s Commercial Real Estate Group.

About Penton Media, Inc.

As a leading, independent, business-to-business media company, Penton knows business and how to create and disseminate the vital content that moves markets.? Penton is where professionals turn to gain the critical insight, expert analysis, and relevant connections needed to compete and succeed.? The Company is headquartered in New York City with approximately 1,100 employees across key locations throughout the world including New York; Cleveland; Chicago; Overland Park, Kansas; Boulder, Colorado; Fort Collins, Colorado; and Hong Kong.? Penton is a privately held company owned by MidOcean Partners and U.S. Equity Partners II, an investment fund sponsored by Wasserstein Co., LP, and its co-investors. For additional information on the company and its businesses, visit www.penton.com.

About National Real Estate Investor

National Real Estate Investor is the industry?s leading digital and print source on commercial real estate trends and for readers representing a cross-section of disciplines ? brokerage, construction, owner/development, finance/investment, property management, corporate real estate, and real estate services.? For additional information, visit www.nreionline.com.

CONTACT:Neta Yoffe, Corporate CommunicationsPenton Media, Inc.Phone: (212) 204-4259Email: neta.yoffe@penton.com

SOURCE Penton Media, Inc.

Article source: http://www.sacbee.com/2012/02/07/4246250/sam-zell-comes-clean-for-pentons.html

Source: http://www.rankinrealty.net/2012/02/sam-zell-comes-clean-for-pentons-national-real-estate-investor-nreionline-com/

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Wednesday, February 8, 2012

Classic sooty-moth tale bolstered by new results

Backyard experiment strengthens scenario for evolutionary changes due to pollution

Web edition : 12:33 pm

A recently criticized textbook example of evolutionary forces in action, the dark forms of peppered moths that spread with industrialization in Britain, may be on its way back.

Results of an ambitious experiment on the moths (Biston betularia) support the original hypothesis that their dark-colored forms spread in soot-coated landscapes because they are more difficult for hungry birds to spot, says evolutionary biologist James Mallet of Harvard University. He and three colleagues have published the final peppered moth experiment of Michael Majerus, who spent six years monitoring the fates of a total of 4,864 moths, presented his conclusions at a conference but died before publishing them. The study appeared online February 8 in Biology Letters.

The moth story not only makes ?a compelling example of evolution in action,? but it?s ?a terrific case history of how science works,? says evolutionary biologist Scott Freeman of the University of Washington in Seattle. ?Majerus raised questions; he and his colleagues did the hard work required to answer them.?

The moths, which usually have salt-white wings sprinkled with pepper-black, have long played a role in evolutionary biology. In the early years of genetics, breeding experiments established that a single gene can create a black form. It showed up in Manchester, England, in 1848, and by 1895, 98 percent of the region?s moths were dark. Moths went dark in similarly industrializing areas, and when clean-air regulations began to clear the pollution, dark forms went into decline.

Experiments in the mid-20th century supported the idea that industrial grime provided better camouflage for dark wings, but that work drew escalating challenges starting in the 1990s. Majerus and other scientists raised questions about those studies? methods, such as whether the high densities of moths released had altered the results and whether the tree trunks where moths were placed were a normal resting place. Debates over those studies ignited reputation bashing, charges of fraud and a firestorm of creationist glee.

Majerus, who lived in a relatively unpolluted hamlet near Cambridge, England, set out to answer some of the questions himself. On spring and summer mornings he rose before dawn to climb ladders and set out eight to 10 moths on realistic spots in the trees behind his home. He then checked to see if they survived the first four hours of daylight.

After six years of moth patrol, he established that dark forms had only about 91 percent the survival rate of the light moths. That kind of predation pressure was strong enough to account for the shift in moth forms, he concluded.

Majerus also established that a noticeable portion (36 percent) of moths do choose to rest on tree trunks, and he tested, and rejected, the alternative hypothesis that bats instead of birds were differentially catching light or dark moths. Birds indeed were eating the moths; Majerus witnessed many of the fatalities from his window.

The storied moth may one day find its way back into textbooks, though perhaps in new forms. Freeman says he considered including it in his introductory textbook with new material on dark moth forms spreading in gritty North American districts. And author Kenneth Miller of Brown University says he?s thought about discussing peppered moths along with color forms of rock pocket mice to explain natural selection?s influence on dark-pigmented forms.

?In short,? Miller says, ?the peppered moth story is and always was a fine example of natural selection in action.?
Found in: Environment and Life

Source: http://www.sciencenews.org/view/generic/id/338230/title/Classic_sooty-moth_tale_bolstered_by_new_results

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Tuesday, February 7, 2012

Plenty of outrage over Diaz-Condit decision, winner defends his approach

Defense is an underrated aspect of mixed martial arts. That's unless you're a judge.

Carlos Condit picked his spots and had Nick Diaz whiffing with his punches for much of the night at UFC 143. His strategy and executed resonated with the judges, who scored it 4-1, 4-1 and 3-2 in favor of the new UFC interim welterweight champ. But Condit's ring generalship didn't go over well with many fans.

Here's sampling of tweets from fights fans who thought Condit simply ran the entire night.

Condit didn't see it that way.

"I was pretty confident that I had won the fight. I landed a lot of effective strikes. I stuck to my gameplan. I did what I went in there to do. I punched him in the face. Kicked him in the face. You know, landed more effective strikes than he did in the fight," Condit said. "That's what it boiled down to. If I sat there and fought Nick Diaz's fight, it'd probably be him sitting here with this belt instead of me."

UFC president Dana White agreed.

"The fans are mad about the way Carlos Condit fought ... too [expletive bad]. You're mad at the way he fought? He went in there and he fought a great fight," White said. "He stuck to his gameplan. Nick Diaz is the master of getting you to fight his fight. [...] Carlos Condit kept his cool tonight. He fought a perfect fight."

Condit said when did Diaz did catch him, the shots were weak.

"They weren't all that effective. For the most part, if he did hit me with anything, it was kind of past the power zone. They didn't have a lot on them," said Condit.

Condit thought his kicks paid dividends later in the fight.

"Chopping his legs and affecting his mobility from the very start was working," Condit said. "You don't see the effects of that until later on in the fight. But he stopped coming forward on me."

As Diaz began to talk trash, Condit also stayed under control. He recalled one funny line when Diaz responded to one of the 10-plus spinning backfists and elbows that Condit threw his way.

"We're throwing spinning [expletive] now?," Condit said repeating what Diaz said in the cage. Condit wasn't about to play Diaz's mind games.

"I planned for that. I knew that I to be mentally prepared as well as physically prepared to face Nick Diaz," Condit said. "That's something I had in my mindset as well as the talking and the taunts and stuff. I just needed to stay focused and execute my gameplan. No matter what he said or no matter how many punches he took from me, I couldn't let my focus stray."

What's next for Condit is anyone's guess. The fighter and promotion were non-committal on when he gets back in the Octagon. The champ Georges St-Pierre is hoping for a November return from ACL surgery. Nine months is a long time for the top of the 170-pound division to stay dormant.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/plenty-outrage-over-diaz-condit-decision-winner-defends-105756633.html

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About Internet Business: A proper SEO learning session

By Williamo Mountasoso

Search engine marketing just isn't a bad thing once you take into account each of the potential benefits, and not to mention that you simply can make tons of income, possibly. Ever considering that the late 90s when Google 1st happened on the net, men and women have been employing all kinds of strategies to rank very and produce targeted site visitors. Google's main concern would be to provide the best outcomes for their visitors, and that is certainly their product - pertinent search results. But you'll be able to nevertheless beat the Seo game if you want, and we very advise you get expertise of the fundamentals, and that will take you really far. So if you are just beginning out with Search engine marketing, then the following few simple suggestions really should enable you to have a fantastic start.

To be able to get important feedback about your efforts, it's necessary to understand your precise rankings in the search engines like google. When your internet site is reside, then uncover a reliable and verified service for taking care of all your backlinks. Much is dependent upon your niche and your keywords, and that will determine a great deal as far as how fast or slow you move up, or down, the rankings. This can be all truly pretty cut and dry because you've to help keep up the work to get to the top rated and then remain there. Now let's turn out attention towards the images on your pages because they are beneficial. That is why you shouldn't ignore the significance of optimizing the images on your page. Incorporate a relevant keyword or phrase in the image ALT tag that is component in the file name, but don't keyword stuff. Everything has to become related on every page, so your alt tag keyword or phrase ought to naturally stick to that, too. Just be certain you stay away from wanting to do something tricky right here since it'll not be effective.

Blackhat Search engine marketing is basically carrying out items that are not accepted by the search engines, and lots of people view it as cheating and unethical. If you'd like to learn about it, it is possible to, but you really should take care in regards to the whole proposition.

Yes, some blackhat methods are effective, so we leave it up to you as to what floats your boat. The opposite of that's whitehat Seo, and which is the mainstream and acceptable strategy to approach it.

Stay away from attempting to do issues the low cost way with gimmicks along with the like with Search engine optimisation because they never ever final for lengthy. If you are going to take it easy, then even the results you get will not be serious. If you'd like to create the sort of organization it is possible to count on later on, then you know what you've got to complete. Your best outcomes will occur with all the appropriate approach, and you might have to obtain further understanding to do that. Search engine optimisation can get boring, nevertheless it is some thing that has to be done if you want those search rankings.



About the Author:


Learn more about seo for dentists. Stop by Adriane Graham's recommended site where you can find out all about budget SEO and what it can do for you.

Source: http://about-internet-business.blogspot.com/2012/02/proper-seo-learning-session.html

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Monday, February 6, 2012

Mars co-operation near collapse

The American space agency looks set to pull the plug on its joint missions to Mars with the European Space Agency.

Nasa has told Esa it is now highly unlikely it will be able to contribute to the endeavours, which envision an orbiting satellite and a big roving robot being sent to the Red Planet.

The US has yet to make a formal statement on the matter but budget woes are thought to lie behind its decision.

Europe is now banking on a Russian partnership to keep the missions alive.

A public announcement by Nasa of its withdrawal from the ExoMars programme, as it is known in Europe, will probably come once President Obama's 2013 Federal Budget Request is submitted.

This request, expected in the coming days, will give the US space agency a much clearer view of how much money it has to implement its various projects.

"The Americans have indicated that the possibility of them participating is now low - very low. It's highly unlikely," said Alvaro Gimenez, Esa's director of science.

"They are interested, they know it's a very good option for them - but they have difficulties putting these missions in the budget," he told BBC News.

"We have to wait for the Americans to have a definitive say, but we also have to study alternatives."

The pull-out by Nasa - if that is confirmed - will be just the latest twist in what has been a long running saga, and it will leave Europe's Mars ambitions in a precarious position.

Continue reading the main story

The 2016 ExoMars orbiter

  • It would study Mars' atmosphere for sources of methane and other trace gases
  • Methane is intriguing because its presence could indicate biological activity
  • 2016 would act as the relay station for the 2018 rover when it arrives at Mars
  • It would also demonstrate some limited European technologies for landing on planets

As currently planned, ExoMars would see an orbiting satellite launched in 2016 to "sniff" for methane and other trace gases in the Martian atmosphere, followed by an autonomous rover in 2018 to drill beneath the planet's surface.

The Americans were supposed to be providing instruments and a communications package for the orbiter, and a great swathe of equipment for the rover, in addition to the rocket to send it on its way and the descent system to get the robot safely down on to the Martian terrain.

Concerns last year in the US about the state of Nasa's Mars budget had already prompted Esa to inquire whether the Russian space agency (Roscosmos) would be interested in entering the ExoMars programme.

But the latest signals from Washington have now pushed Esa into discussing a full bi-lateral agreement, with the intention that Roscosmos pick up many of the responsibilities expected to be dropped by the Americans.

This would include instruments for the orbiter and the provision of two Proton rockets to get both missions to their destination.

It could not be a straight substitution of roles, however, because the Russians do not possess all of the skills that Nasa was proposing to bring to ExoMars.

For Europe, it means returning to an earlier, smaller design for the 2018 rover. It would also have to resurrect ideas it had for vented, or dead-beat, airbags to cushion the vehicle's touch-down.

But the technical challenges of having to reframe the ExoMars missions may pale in comparison to the difficulties of meeting the additional costs involved.

Changes in architecture would inevitably push the budget profile beyond the one billion euros that Esa member states had agreed should be the cap for ExoMars.

"I cannot pretend the situation is not grim," commented Dr David Parker, director of science, technology and exploration at the UK Space Agency (UKSA).

Continue reading the main story

The 2018 ExoMars rover

  • Envisioned as a near one-tonne rover equipped with a suite of science instruments
  • Its design would emulate a rover Nasa launched to Mars in November (above)
  • It would probably cache interesting rocks for return to Earth on a later mission
  • American withdrawal would mean Europe returning to an earlier, smaller design

"It's come as a major surprise to us that the Americans don't want to play. We now have to take some cold, sensible decisions about what we do with public money, and it may be that some national activities will have to be put in the deep freeze until we have a clearer sense of what is going to happen."

ExoMars was formally initiated in Europe by ministers in 2005. Esa has already spent in the region of 200 million euros on technology development, and would be loath to give up on the flagship project.

"ExoMars is really important for Europe and its role in future exploration," said Dr Gimenez.

"It's important for science and it's important for industry. There are a host of reasons to continue with ExoMars and that is why I am working so hard to try to make it happen," he told BBC News.

A Nasa pull-out of ExoMars would be met with dismay by American planetary scientists.

The 2016 and 2018 missions were seen as the first steps in a series of missions that would lead to the eventual return of Martian rocks for study in Earth laboratories.

A recent panel reviewing the future of US planetary science considered this goal to be a top priority.

Withdrawal also has grave implications for transatlantic relations.

The US has already left Europe high and dry on several projects of late. Last year, it walked away from three multi-billion euro missions-in-the-planning, forcing European scientists and engineers to head back to the drawing board after three years of feasibility work.

Asked to comment on developments, Nasa HQ in Washington told the BBC: "Even in these times of fiscal restraint, President Obama has laid out an ambitious plan of exploration and discovery for Nasa that includes robotic missions to Mars as well as the ultimate goal of a human mission. It would not be appropriate to comment on specifics of the president's budget before it is released on 13 February."

Jonathan.Amos-INTERNET@bbc.co.uk and follow me on Twitter

Source: http://www.bbc.co.uk/go/rss/int/news/-/news/science-environment-16906740

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Hitachi Automotive Methods to construct a third plant in Kentucky ...

Governor Steve Beshear these days joined community leaders and officials from Hitachi Automotive Programs Americas Inc. to announce the business has selected Berea, Kentucky for its third production facility from the Commonwealth. The brand new plant, which can produce electric push motors for hybrid and electric vehicles, will establish a hundred thirty new work and a even more than $74.five million investment from the state.

Hitachi is actually a shining star in Kentuckys automotive trade, Gov. Beshear claimed. Not only will this newest expansion deliver Hitachis Berea workforce to even more than 1,070, in addition, it enhances Kentuckys profile from the highly developed hybrid automotive trade. Ended up positioning Kentucky to become the epicenter of this highly developed automotive production trade, and potent relationships with providers like Hitachi are a cornerstone of our achievement.

Hitachi, which has present areas in Harrodsburg and Berea, has purchased a 151,000 square-foot facility on 65 acres in Berea for its newest venture. The plant, which accustomed to produce electrical programs, might be 100 % retooled and will now manufacture motors that could electric power highly developed hybrid electric powered vehicles, for example the Chevy Volt. Moreover, Hitachis long term strategies include the creation of other hybrid vehicle programs like lithium-ion batteries and electric inverters to be manufactured in its Kentucky vegetation.

Hitachi also introduced an expansion of its Harrodsburg plant from the fall of 2009, adhering to the Governors financial progression trip to Japan. Throughout the trip, Gov. Beshear met with Hitachi officials to examine several opportunities for that companys development from the Commonwealth. The venture, which later grew substantially in scope, represents a $68 million investment and 145 new work in Harrodsburg.

Operations in the new plant in Berea are predicted to start in late 2011, with strategies to ship the 1st electric motors from its Madison County factory in mid-2012.

Hitachi has become the number of automotive suppliers using the functionality to acquire and produce our have lithium-ion batteries, electric push motors together with the electronic controls wanted to manage hybrid electric vehicles, claimed Hitachi Automotive Programs Americas President Mark Fujisawa. We?re thrilled to open up this new factory that could give increased employment prospects for that state coupled with spearheading Hitachis production of hybrid electric vehicle motors for U.S. potential customers.

The Kentucky Economical Development Finance Authority (KEDFA) preliminarily accepted Hitachi for tax incentives up to $4 million through the Kentucky Firm Investment software. The performance-based incentive will allow for the business to help keep a part of its investment in excess of the phrase of this agreement because of corporate cash flow tax credits and wage assessments by meeting work and investment targets.

KEDFA also accepted Hitachi for tax gains up to $100,680 through the Kentucky autorit s autrichiennes Enterprise Investment Act, which will allow for accepted providers to recoup Kentucky sales and use tax on building charges, setting up fixtures, devices used in homework and progression and electronic processing devices. An Economical Development Bond grant from the sum of $500,000 was also accepted for that town of Berea for that advantage of this Hitachi venture.

I?m proud to be part of this community that could be household to an exquisite workforce that can provide providers the individuals they require, claimed Sen. Jared Carpenter, of Berea. We?re excited to discover Hitachi make this massive investment in Berea and Madison County.

This investment will be the form of financial raise our Commonwealth necessities by delivering work and chance to the workforce in Madison and surrounding counties, claimed Rep. Lonnie Napier, of Lancaster. Todays announcement speaks volumes in regards to the good quality of workers together with the favorable financial local weather now we have in Kentucky.

Hitachi is actually a firm that builds achievement on common values and innovation, claimed Berea Mayor Steven Connelly. When we realized that it would expand its automotive operation in Berea, our citizens and elected officials had been deeply honored and very excited in regards to the long term. We?re assured the partnership somewhere between Berea and Hitachi will keep going to grow and prosper into the 21st Century under Hitachis inspired leadership.

That is this sort of an exquisite announcement, notably in the existing time, from the existing market, claimed Madison County Judge-Executive Kent Clark. As normally, considerably of this credit score need to go to Hitachi executives, Tom McCay and his workers as well as to the good quality of life that could be one of a kind to Madison County, Kentucky.

Hitachi Automotive Programs Americas Inc. manufactures electronic and mechanical automotive pieces selling to many of the worlds major automotive production providers. Hitachi Automotive Programs Americas Inc. commenced production operations from the Commonwealth of Kentucky in 1986. The business delivers automotive electronics in Harrodsburg, Kentucky, and automotive suspension and brake programs in its factories in Berea, Kentucky. Hitachis Madison County electric motor factory might be Hitachis third automotive production operation in Kentucky and raises Hitachis employment from the Commonwealth to in excess of 1700 staff members.

To find out more on Hitachi Automotive Programs Americas, go to .

Related posts:

  1. Earn More with Automotive jobs
  2. Normal Electric Monogram Appliances

Source: http://www.empidlnc.org/hitachi-automotive-methods-to-construct-a-third-plant-in-kentucky/

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Sunday, February 5, 2012

IRS Tax Debt Relief ? Ideal Tax Relief ? aminuu.com

Internal Revenue Services, or even commonly known as IRS, can be a tax selection company that implements unpleasant steps and fines on the people that turn out to become tax evaders. If you are in an issue which you have to cope with IRS, then you should consider a number of specialist. The assist can become sought at Internet with there being several online tax aid businesses that allow you to solve the tax connected troubles. These businesses possess remarkably qualified specialists that will can remedy the IRS tax problems. These people, aside from filling your earnings tax return, will also help by communicating on account along with work out along with government authorities to enhance your tax rebate.

If you are intending to handle IRS on your own, it can become very troubling and hard.

If you get to know that you?ve taxes that are late and also you will be unable to settle all of them on time, then you might begin accumulating late fees and other money because fines. It is vital to take control of delinquent taxes because they can get out and about of control rapidly.

Should you be determined to work on the tax troubles on your own personal, then you need to cope with IRS and work out and about on settlement plans. It needs to be known that IRS can be an organization which is extremely stringent featuring its policies and is really firm to any alter.

The most significant point that?s needed is while working with IRS will be honesty. You?ve to trustful and cannot rest in nevertheless. Just about any rest talked, will always be trapped and also you will placed to adverse penalties. Credibility can be the only policy in which can help you move further and also can help you plan an actions whereby an individual can shell out back the money which you owe to IRS.

You must preserve in mind that it is very difficult to reduce your tax debt on your own personal. You should employ a tax debt relief consultant, as he will help you just about all along the method.

There are several complex concerns, that you just may encounter while managing IRS there are lots of document filling up that requires proper help.

So if you?re seeking for a professional attorney to work on the IRS associated Tax debt relief, after that these are several elements that you should retained in mind:

- The lawyer that you?re selecting must have years on encounter and may always be a professional in the associated field.

- If needed, an individual can acquire references from some other lawyers to find the best-suited legal professional.

IRS tax debt relief is something which can become dealt with in a number of ways. If you?re working with the debt on your individual, then it?s quite necessary to make suitable preparations. However a specialist is obviously proposed. In case in case you are in the middle of the debate with IRS, next in addition, you can hire an lawyer as in this sort of circumstances the IRS prevents and also reschedules the conversation.

For more information, go to Tax Relief as well as Tax debt Relief

Source: http://aminuu.com/finance/taxes/irs-tax-debt-relief-ideal-tax-relief/

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Wednesday, February 1, 2012

When the isolated lung runs out of air

When the isolated lung runs out of air [ Back to EurekAlert! ] Public release date: 1-Feb-2012
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Contact: Dr. Kathrin Bilgeri
kathrin.bilgeri@lmu.de
49-892-180-6938
Ludwig-Maximilians-Universitt Mnchen

Source of damage to donor organs identified

For patients with incurable pulmonary conditions, a lung transplantation is the only available treatment option. However, suitable donor organs are scarce, and even getting them to prospective recipients is not easy. As Professor Alexander Dietrich of the Walther Straub Institute of Pharmacology and Toxicology at LMU explains, "An isolated lung which is no longer perfused with blood can become so severely damaged that it is no longer functional. This so-called ischemia-reperfusion injury is one of the major problems in the field of lung transplantation." Together with his colleague Professor Thomas Gudermann, and in collaboration with a team of researchers led by Professors Norbert Weissmann and Werner Seeger at Giessen University, Dietrich has succeeded in identifying the underlying mechanism that leads to the life-threatening loss of pulmonary function. It turns out that, in the isolated, unperfused lung, the endothelial cells that form the innermost layer of the blood vessels lose their function as a vascular barrier. This allows water and cells of the immune system to penetrate into the tissues, where they can provoke inflammatory reactions. Two regulatory proteins that control the permeability of the blood vessels in the lung play a crucial role in this process. "Our findings should make it possible, for the first time, to use specific inhibitors and to develop pharmaceutical agents with which we can reduce or prevent ischemia-reperfusion injury in the future," says Dietrich. (Nature Communications, 31.01.2012)

Lungs removed from a donor are no longer actively perfused with blood, and soon suffer from the lack of adequate levels of oxygen. Hence they become "ischemic" during transport to the prospective recipient, leading to so-called ischemia-reperfusion damage. This condition constitutes a major, indeed life-threatening complication for lung transplantation, and may lead to failure of the transplanted and reperfused lung. Since the demand for donor lungs greatly exceeds the available supply, the discovery of a means of preventing ischemia-reperfusion injury would represent a major breakthrough in the field. The LMU researchers led by Dietrich and Gudermann, in cooperation with Weissmann and Seeger and their colleagues in Giessen, set out to identify the cell types and the signal molecules that play a role in the development of the condition, with a view to developing ways of attenuating its course. To this end, they created mutant mouse strains that are unable to synthesize particular proteins. This allowed them to dissect the effects of these factors on the induction of ischemia-reperfusion injury, both in the whole animal and in the isolated lung. In an extensive series of experiments on single, isolated endothelial cells obtained from the pulmonary blood vessels of the various mouse strains, they characterized the effects of the different mutations on the barrier function of the cells, and on the pattern of calcium currents across the endothelial cell membrane, under ischemic conditions.

"To our surprise, we found that increased permeability of the endothelial cells is primarily responsible for the initial phases of ischemia-reperfusion injury, because this allows fluid and immune cells to penetrate into the tissue," says Dietrich. This in turn results in inflammation and extensive destruction of lung tissue, and ultimately leads to major loss of lung function. The investigators also identified two central regulators of pulmonary endothelial cell permeability the so-called NADPH oxidase 2 (Nox2) and the calcium channel TRPC6 and were able to work out how these proteins are activated. Reactive oxygen species produced by the enzyme Nox2 trigger a signal cascade that eventually activates TRPC6. As a consequence, increased amounts of calcium enter the endothelial cell which subsequently causes a rise in vascular permeability.

The results of the study suggest that it should be possible to avoid ischemia-reperfusion damage by functionally blocking the two regulatory proteins. Thus, in the next step, the researchers hope to establish an effective therapy for the prevention of ischemia-reperfusion injury in the isolated mouse lung, based on the use of newly identified and more specific inhibitors of TRPC6. In the longer term, this could lead to ways of preventing, or at least reducing, damage to donor lungs on their way to their prospective recipients.

###

The project has been supported by the German Research Foundation (DFG) and the German Center for Lung Research (DZL). (gd/PH)

Publication:

Activation of TRPC6 channels is essential for ischemia-reperfusion-induced lung edema in mice. N. Weissmann, A. Sydykov, H. Kalwa, U. Storch, B. Fuchs, M. Mederos y Schnitzler, R. P. Brandes, F. Grimminger, M. Meissner, M. Freichel, S. Offermanns, F. Veit, O. Pak, K.-H. Krause, R.T. Schermuly, A.C. Brewer, H.H.H.W. Schmidt, W. Seeger, A.M. Shah, T. Gudermann, H.A. Ghofrani & A. Dietrich. Nature Communications, Online Publication 31.1.2012. DOI: 10.1038/ncomms1660

Contact:

Professor Dr. Alexander Dietrich
Walther Straub Institute for Pharmacology and Toxicology, LMU
Phone: 49-89/2180-73802
Fax: 49-89/2180-73801
Email: Alexander.Dietrich@lrz.uni-muenchen.de

Professor Dr. Thomas Gudermann
Walther Straub Institute for Pharmacology and Toxicology, LMU
Phone: 49-89/2180-75700
Fax: 49-89/2180-75701
Email: Thomas.Gudermann@lrz.uni-muenchen.de



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Contact: Dr. Kathrin Bilgeri
kathrin.bilgeri@lmu.de
49-892-180-6938
Ludwig-Maximilians-Universitt Mnchen

Source of damage to donor organs identified

For patients with incurable pulmonary conditions, a lung transplantation is the only available treatment option. However, suitable donor organs are scarce, and even getting them to prospective recipients is not easy. As Professor Alexander Dietrich of the Walther Straub Institute of Pharmacology and Toxicology at LMU explains, "An isolated lung which is no longer perfused with blood can become so severely damaged that it is no longer functional. This so-called ischemia-reperfusion injury is one of the major problems in the field of lung transplantation." Together with his colleague Professor Thomas Gudermann, and in collaboration with a team of researchers led by Professors Norbert Weissmann and Werner Seeger at Giessen University, Dietrich has succeeded in identifying the underlying mechanism that leads to the life-threatening loss of pulmonary function. It turns out that, in the isolated, unperfused lung, the endothelial cells that form the innermost layer of the blood vessels lose their function as a vascular barrier. This allows water and cells of the immune system to penetrate into the tissues, where they can provoke inflammatory reactions. Two regulatory proteins that control the permeability of the blood vessels in the lung play a crucial role in this process. "Our findings should make it possible, for the first time, to use specific inhibitors and to develop pharmaceutical agents with which we can reduce or prevent ischemia-reperfusion injury in the future," says Dietrich. (Nature Communications, 31.01.2012)

Lungs removed from a donor are no longer actively perfused with blood, and soon suffer from the lack of adequate levels of oxygen. Hence they become "ischemic" during transport to the prospective recipient, leading to so-called ischemia-reperfusion damage. This condition constitutes a major, indeed life-threatening complication for lung transplantation, and may lead to failure of the transplanted and reperfused lung. Since the demand for donor lungs greatly exceeds the available supply, the discovery of a means of preventing ischemia-reperfusion injury would represent a major breakthrough in the field. The LMU researchers led by Dietrich and Gudermann, in cooperation with Weissmann and Seeger and their colleagues in Giessen, set out to identify the cell types and the signal molecules that play a role in the development of the condition, with a view to developing ways of attenuating its course. To this end, they created mutant mouse strains that are unable to synthesize particular proteins. This allowed them to dissect the effects of these factors on the induction of ischemia-reperfusion injury, both in the whole animal and in the isolated lung. In an extensive series of experiments on single, isolated endothelial cells obtained from the pulmonary blood vessels of the various mouse strains, they characterized the effects of the different mutations on the barrier function of the cells, and on the pattern of calcium currents across the endothelial cell membrane, under ischemic conditions.

"To our surprise, we found that increased permeability of the endothelial cells is primarily responsible for the initial phases of ischemia-reperfusion injury, because this allows fluid and immune cells to penetrate into the tissue," says Dietrich. This in turn results in inflammation and extensive destruction of lung tissue, and ultimately leads to major loss of lung function. The investigators also identified two central regulators of pulmonary endothelial cell permeability the so-called NADPH oxidase 2 (Nox2) and the calcium channel TRPC6 and were able to work out how these proteins are activated. Reactive oxygen species produced by the enzyme Nox2 trigger a signal cascade that eventually activates TRPC6. As a consequence, increased amounts of calcium enter the endothelial cell which subsequently causes a rise in vascular permeability.

The results of the study suggest that it should be possible to avoid ischemia-reperfusion damage by functionally blocking the two regulatory proteins. Thus, in the next step, the researchers hope to establish an effective therapy for the prevention of ischemia-reperfusion injury in the isolated mouse lung, based on the use of newly identified and more specific inhibitors of TRPC6. In the longer term, this could lead to ways of preventing, or at least reducing, damage to donor lungs on their way to their prospective recipients.

###

The project has been supported by the German Research Foundation (DFG) and the German Center for Lung Research (DZL). (gd/PH)

Publication:

Activation of TRPC6 channels is essential for ischemia-reperfusion-induced lung edema in mice. N. Weissmann, A. Sydykov, H. Kalwa, U. Storch, B. Fuchs, M. Mederos y Schnitzler, R. P. Brandes, F. Grimminger, M. Meissner, M. Freichel, S. Offermanns, F. Veit, O. Pak, K.-H. Krause, R.T. Schermuly, A.C. Brewer, H.H.H.W. Schmidt, W. Seeger, A.M. Shah, T. Gudermann, H.A. Ghofrani & A. Dietrich. Nature Communications, Online Publication 31.1.2012. DOI: 10.1038/ncomms1660

Contact:

Professor Dr. Alexander Dietrich
Walther Straub Institute for Pharmacology and Toxicology, LMU
Phone: 49-89/2180-73802
Fax: 49-89/2180-73801
Email: Alexander.Dietrich@lrz.uni-muenchen.de

Professor Dr. Thomas Gudermann
Walther Straub Institute for Pharmacology and Toxicology, LMU
Phone: 49-89/2180-75700
Fax: 49-89/2180-75701
Email: Thomas.Gudermann@lrz.uni-muenchen.de



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-02/lm-wti020112.php

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